NFIC | Recognizes and binds the palindromic sequence 5’-TTGGCNNNNNGCCAA-3’ present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. |
NKX2-5 | This gene encodes a member of the NK family of homeobox-containing proteins. Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. |
NOBOX | This homeobox gene encodes a transcription factor that is thought to play a role in oogenesis. |
NR2E3 | This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. |
NR2F1 | Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. |
NR3C1 | Glucocorticoids regulate carbohydrate, protein and fat metabolism, modulate immune responses through suppression of chemokine and cytokine production and have critical roles in constitutive activity of the CNS, digestive, hematopoietic, renal and reproductive systems. |
NR4A2 | Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. |
PAX2 | Probable transcription factor that may have a role in kidney cell differentiation. |
SOX17 | Acts as transcription regulator that binds target promoter DNA and bends the DNA. |
SP1 | Can activate or repress transcription in response to physiological and pathological stimuli. Regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. |
SPI1 | This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. |
SPZ1 | This gene encodes a bHLH-zip transcription factor which functions in the mitogen-activate protein kinase (MAPK) signaling pathway. |
TFAP2A | The protein encoded by this gene is a transcription factor that binds the consensus sequence 5’-GCCNNNGGC-3’ and activates the transcription of some genes while inhibiting the transcription of others. |
USF1 | This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular. transcription factor. |
YY1 | Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site |
ZEB1 | This gene encodes a zinc finger transcription factor. Acts as a transcriptional repressor. |
ZFX | A member of the krueppel C2H2-type zinc-finger protein family and probable transcriptional activator. |
ZNF354C | May function as a transcription repressor. |